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Capsaicin 8% patch in painful diabetic peripheral neuropathy: a randomized, double-blind, placebo-controlled study

Side effect profiles also differ: semaglutide is more associated with nausea, while tirzepatide more commonly causes diarrhea

The company is on track to launch its own oral tirzepatide (orforglipron) as early as Q2, pending FDA approval

By acting on both GLP-1 and GIP receptors, Tirzepatide provides a more comprehensive treatment, helping the body better regulate blood sugar and reduce food intake

Real-world reports describe new or worsened anxiety in a small subset of patients, often linked to blood sugar swings, side effect burden, or rapid weight loss stress